By constructing humanized animal models to modify the host, such as transplanting human hematopoietic stem cells or human liver cells into immunodeficient mice to carry functional human immune cells or target organs, the interaction between engineered bacteria and human cells can be evaluated in a living environment
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Answer and interpretation This is probably valproic acid induced hyperammonia encephalopathy (VHE) VHE has been reported secondary to acute VPA overdose and in chronic normal therapeutic dosing, presenting as an acute and profound decreased level of consciousness, with or without increased seizure activity this is usually in association with an increased serum ammonia level (Mock and Schwetschenau, 2008) Patients at higher risk for VHE include those with liver impairment, on multiple anticonvulsants, or have other causes of increased ammonia production
